Studies report that Myrrh (Commiphora Myrrha) and Frankincense (Boswellia Carterii) both have significant Analgesic and Anti-inflammatory effects. For this reason, both herbs are often combined for treating diseases related to inflammatory pain with synergistic therapeutic effect.
The study in question investigated the anti-inflammatory activities of both herbs by inducing paw edema in mice using formalin and carrageenan. In addition, the study determined the levels of PGE2 (Prostaglandin 2) and nitrite oxide (NO) in the mice’s paw edema. Where PGE2 is responsible for the inflammation in the body. And NO is released by the body in places of inflammation, where NO kills pathogens and causes vasodilation in the surrounding area. The analgesic activity was examined against oxytocin-induced dysmenorrhea (swelling) in mice. The effects of the administration of dolantin or indomethacin were also studied for references. The two herbal components in combination extract (CWE) were analyzed by UPLC-MS/MS.
The results showed that myrrh water extract (MWE) and the combined extract (CWE) at the 3.9 g/kg, and 5.2 g/kg showed inhibition of formalin-induced paw edema with inhibition rate of 30.44%, and 23.50%, respectively. The PGE(2) production was inhibited significantly by all samples (P<0.01 or P<0.05). CWE showed stronger suppression on carrageenan-induced mice paw edema at 2 and 3h after administration of drugs. The inhibitory effect of CWE on nitrite production was between that of MWE and water extract of frankincense (FWE) at 5.2 g/kg. The dysmenorrhea mice test showed MWE could remarkably reduce the writhing times (P<0.05) and prolong the latency period, while FWE showed no obvious effects on the writhing times. CWE significantly reduced the writhing times and prolong the latency period (P<0.01).
These results demonstrated MWE, FWE, and CWE exhibited significant anti-inflammatory and analgesic activities. The findings suggest that CWE may be therapeutically more useful for mitigating inflammatory pain than either Frankincense or Myrrh alone. In addition, 12 potential active compounds were identified from CWE. These data may support the fact the traditional application of this combined extract in treating various diseases associated with inflammatory pain.
In my own experience, Myrrh is an excellent Analgesic topically & dentally. I personally had wisdom teeth erupting from the back of my mouth, with the gum stuck between my teeth. Such that every bite was painful. I didn’t have anything to numb the pain. But I remembered that Myrrh was used traditionally for dental health. So to relieve the pain and infection, I gargled a drop of Myrrh oleoresin with water. I first felt a mild stinging in my mouth. Then to my amazement, the pain totally disappeared in moments. With following applications, the infection I had also calmed down.
My other observation is that you must carefully use Myrrh and Frankincense internally. Especially Myrrh for those with sensitive stomachs. Because of Myrrh’s astringent properties, it is best to take Myrrh with food or fruit juice in order not to disturb the bacterial populations in your gut. On it’s own, Myrrh acts as an antibiotic and kills much of the gut flora in our digestive system. The result is dysentery.
Author: Raqib Zaman