Answer by Debbie Boykin:

Methylene blue (MB) is an under-utilized nootropic. MB is currently being investigated for the treatment of Alzheimer’s by TauRx.

Methylene blue is really “clean” in the sense that it doesn’t disrupt any neurotransmitter systems the way other Alzheimer’s drugs do like, say, donepzil which increases synaptic levels of acetylcholine.

Instead, methylene blue very cleanly enhances mitochondrial bioenergetics. It accomplishes this by accepting electrons and passing them along the mitochondrial electron transport chain.

Methylene blue is also a special kind of antioxidant. By “special” I mean that it has excellent blood brain barrier penetration (many antioxidants simply never accumulate enough in neural tissue to make a difference), and it is able to self-regenerate. In other words, rather than going on to oxidize cellular components after a redox reaction, it autoxidizes to regenerate its antioxidant capacity.

To learn more about methylene blue, take a look at this article: Repairing Synaptic Wear-and-Tear with Methylene Blue: Dosage, Safety, and Protocol – Brain Protips: Leveraging discoveries in neuroscience to improve brain function

Methylene blue is also available online here: A Cutting Edge, Mood-Brightening Nootropic

What are some commonly overlooked nootropics?

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