Interleukin-10, gut flora, and cancer
Answer by Manjunath Hegde:
A2A. Based on the comments to one of the answer, I am assuming you are looking for a link between IL-10, gut microbiome, and cancer. The hypothesis sounds interesting and early studies in mice look promising. More research will be needed in this area of oncoimmunology before something fruitful comes out of it.
Gut bacteria–host crosstalk is continuous and reciprocal in the cancer macroenvironment. Beneficial microbes trigger IL-10-mediated GI-tract immune and neuronal networks that lower systemic inflammatory tone and up-regulate hypothalamic–hypophyseal targets, including oxytocin, constituting a gut–systemic immunity-endocrine-axis. In this way, microbiota stimulate CD4+lymphocytes including regulatory T cells (TREG) that suppress, promote, or have no effect in carcinogenesis depending upon their timing and prior exposure to gut bacterial antigens and presence of interleukin (IL)-10. This places neoplastic development and growth into a new broader context of the holobiont (comprised of the mammalian host plus resident microbes) and the cancer macroenvironment, highlighting microbes that may be engineered for sustained good health.
If you want to know more about other interleukins (IL-1 to 37), you can see Table 1 in this paper